Lymphoid blastic transformation in chronic myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Chronic myeloid leukemia: mechanisms of blastic transformation.
The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease usually respond to treatment with ABL tyrosine kinase inhibitors (TKIs), although some patients who respond initially later become resistant. In most patients, TKIs reduce the leukemia cell load substantially, but the cells from ...
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We have examined basophil production (BP) in suspension cultures of separated peripheral blood cells from patients with chronic myeloid leukemia (CML). Seventy cultures were performed in 47 patients. 33 in chronic and 1 4 in the accelerated/acute phase of CML. None of 13 normal controls, 0/21 treated chronic phase, 3/33 untreated chronic phase. and 14/18 ( p < 0.0001) accelerated/acute phase CM...
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Using the value of 30 mg/L for serum ferritin as cut off, 861 samples showed iron deficiency (ID) (group A) and 271 were without ID (group B) (Figure 1). The mean HbA2 value was 2.8%±0.79 in group A and 3.50%±1.23 in group B, with a significant difference (P=0.00001) among between the two groups. The distribution of the 253 samples with molecular analysis between groups A and B showed that 170 ...
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Two patients with acute blastic transformation of chronic myeloid leukemia (CML) associated with strikingly elevated platelet counts showed abnormalities of chromosome 3q in addition to the standard Philadelphia (Ph1) chromosome translocation. The first patient had an inversion of chromosome 3 (q21q26) cytologically identical to an inversion 3 previously reported in de novo acute megakaryoblast...
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In order to determine whether antigenic patterns alter with disease progression and are thereby suggestive of impending blast crisis in chronic myelogenous leukemia, 50 bone marrow biopsy specimens from 32 patients were examined retrospectively using indirect immunoperoxidase labeling with three monoclonal antibodies that detect myeloid antigens. Monoclonal antibodies PMN13F6, PMN7C3, and PMN8C...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1994
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.2830460113